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DSIP is a nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) that modulates sleep architecture by promoting stage 3/4 slow waves (delta waves) and regulating circadian rhythms

,,IparN,AydogduSD,YildirimGK,InalM,GiesIVandenplasYet al.Effects of synbiotic on anthropometry, lipid profile and oxidative stress in obese children.2015;6:775782 66

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Therefore, the changes in the gut microbiota after a single injection of GLP-1RA seem to reflect the original effects of GLP-1RA more clearly than the changes in the gut microbiota after chronic administration